In cases of overdose, iron accumulation or intoxication is unlikely with Maltofer Fol due to the low toxicity of iron(III)-hydroxide polymaltose complex (i.e., in mice or rats: lethal dose, 50% (LD50) > 2,000 mg Fe/kg body weight) and controlled uptake of iron. No cases of accidental poisoning with fatal outcome have been reported. There are reports that an excessive dose of folic acid may cause changes to the central nervous system (namely changes in mental state, changes to the sleep pattern, irritability and hyperactivity), nausea, abdominal distension and flatulence.
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